By adding the calcium score to the treatment work-up model, researchers here at the annual scientific sessions of the American Heart Association said that they could reduce the number of patients needed to treat to prevent one event to 19 people — lower even than the 25 to 50 number needed to treat described by the JUPITER investigators.
New research presented from the AHA 2010 in Chicago has demonstrates an Apo B receptor in lipid laden arteriosclerotic plaques. First pass fatty meal digestion results in deposition of chylomicrons from the intestines throught the thoracic duct, into the superior vena cava and directly into the arterioles and into the lipid laden carotid plaque, actually bypassing the liver. Endothelial dysfunction results from high fatty meals, but even worse, first pass chylomicrons are deposited into existing lipid laden plaques.